| Registro completo |
| Provedor de dados: |
MV&Z
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| País: |
Brazil
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| Título: |
A preliminary analysis of the glycosylation pattern of serum IgG following pre-exposure scheme for human rabies vaccine
A preliminary analysis of the glycosylation pattern of serum IgG following pre-exposure scheme for human rabies vaccine
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| Autores: |
Silva, S. R.
Cunha Neto, R. S.
Chaves, L. B.
Faquim-Mauro, E. L.
Silva, A. C. R.
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| Data: |
2013-08-22
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| Ano: |
2013
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| Resumo: |
The currently recommended by WHO for prevention individuals exposed to rabies virus (RV) is pre-exposure prophylaxis (PEP) through the administration of three doses of rabies vaccine by intradermal (ID) or intramuscular (IM) route. The previous study showed that the persistence of protective antibodies titer in the IM schedule is more long-lived, suggesting a different clearance mechanism of antibody. It known that carbohydrate modification of antibodies could induce accelerated clearance or modulate of antibody effector functions. All endogenous IgG antibodies contain an N-linked glycan in the Fc region and about 20% contain glycans elsewhere on the molecule to maintain the two heavy chains of the Fc in an open conformation required for interactions with activating Fcγ receptors (FcγRs).
The currently recommended by WHO for prevention individuals exposed to rabies virus (RV) is pre-exposure prophylaxis (PEP) through the administration of three doses of rabies vaccine by intradermal (ID) or intramuscular (IM) route. The previous study showed that the persistence of protective antibodies titer in the IM schedule is more long-lived, suggesting a different clearance mechanism of antibody. It known that carbohydrate modification of antibodies could induce accelerated clearance or modulate of antibody effector functions. All endogenous IgG antibodies contain an N-linked glycan in the Fc region and about 20% contain glycans elsewhere on the molecule to maintain the two heavy chains of the Fc in an open conformation required for interactions with activating Fcγ receptors (FcγRs).
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.revistamvez-crmvsp.com.br/index.php/recmvz/article/view/3101
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| Editor: |
Conselho Regional de Medicina Veterinária e Zootecnia do Estado de São Paulo
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| Relação: |
http://www.revistamvez-crmvsp.com.br/index.php/recmvz/article/view/3101/2303
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| Formato: |
application/pdf
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| Fonte: |
Revista de Educação Continuada em Medicina Veterinária e Zootecnia; Revista de Educação Continuada em Medicina Veterinária e Zootecnia do CRMV-SP, v. 10, n. 2/3 (2012); 71-72
Revista de Educação Continuada em Medicina Veterinária e Zootecnia; Revista de Educação Continuada em Medicina Veterinária e Zootecnia do CRMV-SP, v. 10, n. 2/3 (2012); 71-72
Revista de Educação Continuada em Medicina Veterinária e Zootecnia do CRMV-SP; Revista de Educação Continuada em Medicina Veterinária e Zootecnia do CRMV-SP, v. 10, n. 2/3 (2012); 71-72
2596-1306
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| Direitos: |
Direitos autorais 2014 Revista de Educação Continuada em Medicina Veterinária e Zootecnia
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